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The End of a DBMS era (by Michael Stonebraker)
Michael Stonebraker just posted a new blog entry about the End of DBMS era. And if he says so, we should at least think about it!
Among other things, he claims that relational dbms can be beaten by approximately a factor of 50 in almost any market (e.g. all major web-search engines use home-brew text software instead of relational DBMS).
Of course, I strongly recommend reading his full blog post
For a different point of view (regarding the scalability of non-rdbms based solutiosn) you can also check this blog post